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Chemical Name 3-Fluorobenzaldehyde
Synonyms 3-Fluorobenzenecarboxaldehyde; 3-Fluorophenylcarboxaldehyde; NSC 66830; m-Fluorobenzaldehyde;
CAS Number 456-48-4
Molecular Formula C₇H₅FO
Appearance Clear Colorless Oil
Molecular Weight 124.11
Storage 4°C, Hygroscopic
Solubility Chloroform, Methanol
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications 3-Fluorobenzaldehyde is a monofluorinated aromatic aldehyde with potential antimicrobial activity. 3-Fluorobenzaldehyde showed inhibitory effects on the activity of mushroom tyrosinase.

The Ultimate Guide to 3-Fluorobenzaldehyde

If you're a chemist, you know the importance of benzaldehyde in organic synthesis. But have you ever heard of 3-fluorobenzaldehyde? This compound is a crucial building block in the production of various pharmaceuticals, agrochemicals, and fragrances. In this ultimate guide, we'll dive deep into the properties, uses, and synthesis of 3-fluorobenzaldehyde.


Learn everything you need to know about 3-Fluorobenzaldehyde - a crucial building block in the production of pharmaceuticals, agrochemicals, and fragrances. Read on for properties, uses, and synthesis of 3-fluorobenzaldehyde.


Benzaldehyde is a colorless liquid with an almond-like odor that is widely used in the synthesis of various organic compounds. One such compound is 3-fluorobenzaldehyde, which is a derivative of benzaldehyde. 3-Fluorobenzaldehyde is an important intermediate in the synthesis of numerous pharmaceuticals, agrochemicals, and fragrances.

What is 3-Fluorobenzaldehyde?

3-Fluorobenzaldehyde is an organic compound with the molecular formula C7H5FO. It is a colorless to pale yellow liquid with a sweet, floral odor. The compound is a derivative of benzaldehyde, in which one of the hydrogens of the benzene ring is replaced by a fluorine atom.

Properties of 3-Fluorobenzaldehyde

The physical and chemical properties of 3-fluorobenzaldehyde are as follows:

  • Molecular Weight: 126.11 g/mol
  • Boiling Point: 198-200°C
  • Melting Point: -19°C
  • Density: 1.16 g/mL at 25°C
  • Flash Point: 93°C
  • Solubility: Insoluble in water, soluble in organic solvents such as ethanol and diethyl ether.

Synthesis of 3-Fluorobenzaldehyde

There are several methods to synthesize 3-fluorobenzaldehyde, but the most common method involves the reaction of fluorobenzene with chloroacetaldehyde in the presence of a catalyst such as copper(I) chloride. The reaction proceeds through a series of intermediate steps, ultimately resulting in the formation of 3-fluorobenzaldehyde.

Applications of 3-Fluorobenzaldehyde

3-Fluorobenzaldehyde is a versatile building block in the synthesis of various pharmaceuticals, agrochemicals, and fragrances. Let's take a closer look at some of the applications of 3-fluorobenzaldehyde.


3-Fluorobenzaldehyde is used as a key intermediate in the synthesis of several important pharmaceuticals. For example, it is a precursor to the antiviral drug Acyclovir, which is used to treat herpes infections. It is also used in the synthesis of Nevirapine, an antiretroviral drug used in the treatment of HIV.


3-Fluorobenzaldehyde is used in the synthesis of various agrochemicals, including insecticides, herbicides, and fungicides. For example, it is used in the synthesis of Flusilazole, a fungicide used to control various fungal diseases in crops such as grapes and cereals.

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