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Tetrahydrofuran
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| Chemical Name | Tetrahydrofuran |
| Synonyms | 2,3,4,5-Tetrahydrofuran; Butane α,δ-Oxide; 1,4-Epoxy-butane; Cyclotetramethylene Oxide; Furanidine; NSC 57858; Oxacyclopentane; Oxolane; THF; Tetramethylene Oxide; |
| CAS Number | 109-99-9 |
| Molecular Formula | C₄H₈O |
| Appearance | Colourless Liquid |
| Molecular Weight | 72.11 |
| Storage | 20°C |
| Solubility | Chloroform (Soluble), Methanol (Soluble) |
| Category | Building Blocks; Miscellaneous; |
| Applications | Tetrahydrofuran is used in a variety of chemical organic synthesis and preparation of various pharmacologically active compounds. |
| Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package |
Tetrahydrofuran: Properties, Uses, and Safety Precautions
Tetrahydrofuran (THF) is an organic compound with the chemical formula (CH2)4O. It is a colorless liquid with a slightly sweet odor that is commonly used as a solvent in various industries. In this article, we will explore the properties, uses, and safety precautions of tetrahydrofuran.
Properties of Tetrahydrofuran: Tetrahydrofuran has the following properties:
- Molecular weight: 72.11 g/mol
- Boiling point: 66 °C (151 °F)
- Melting point: -108.4 °C (-163.1 °F)
- Density: 0.889 g/cm³
- Solubility: Soluble in water, ethanol, and ether
Tetrahydrofuran is a colorless liquid with a slightly sweet odor. It is highly flammable and should be stored away from sources of heat and flame. It is commonly used as a solvent in various industries.
Uses of Tetrahydrofuran: Tetrahydrofuran is used in various industries for the following purposes:
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Pharmaceuticals: Tetrahydrofuran is used as a solvent in the production of pharmaceuticals, such as antibiotics, steroids, and anticancer drugs.
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Polymers: Tetrahydrofuran is used as a solvent in the production of various polymers, such as polyurethane and polytetrahydrofuran.
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Adhesives: Tetrahydrofuran is used as a solvent in the production of adhesives and sealants.
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Chemical synthesis: Tetrahydrofuran is used as a solvent in various chemical reactions, such as the Grignard reaction and the reduction of carbonyl compounds.
Safety Precautions: Tetrahydrofuran is highly flammable and can form explosive peroxides when exposed to air and light. Therefore, it should be stored in a cool, dry place away from sources of heat and flame.
When working with tetrahydrofuran, it is important to wear protective clothing, including gloves and goggles. It should be handled in a well-ventilated area to prevent inhalation of vapors.
Exposure to high concentrations of tetrahydrofuran vapors can cause dizziness, headache, and nausea. Ingestion can cause vomiting and diarrhea. In case of contact or ingestion, seek medical attention immediately.
Conclusion: Tetrahydrofuran is a commonly used solvent in various industries, including pharmaceuticals, polymers, adhesives, and chemical synthesis. It is highly flammable and can form explosive peroxides when exposed to air and light, so it should be handled with proper safety precautions. It is important to store tetrahydrofuran in a cool, dry place away from sources of heat and flame and to handle it in a well-ventilated area to prevent inhalation of vapors.