|Azacyclopentane; Azolidine; Butylenimine; NSC 62781; Perhydropyrrole; Prolamine; Tetrahydropyrrole; Tetramethylenimine;
|Clear Colourless to Pale Yellow Oil
|DMSO, Methanol (Slightly)
|Standards; Natural Products;
|A heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs).
|Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
Pyrrolidine: A Comprehensive Guide to the Chemical Compound
Pyrrolidine is a cyclic organic compound with the molecular formula C4H9N. It is a five-membered heterocyclic compound containing a nitrogen atom in the ring. Pyrrolidine is a versatile compound with various applications in the chemical and pharmaceutical industries. In this article, we will explore the properties, uses, and synthesis of Pyrrolidine.
What is Pyrrolidine?
Pyrrolidine is a colorless, hygroscopic liquid with a boiling point of 87.2 °C and a density of 0.84 g/mL. It is a basic compound with a pKa of approximately 11. The compound has a characteristic odor and is soluble in water, ethanol, and ether. Pyrrolidine is commonly used as a building block in organic synthesis due to its ability to form a variety of derivatives.
History of Pyrrolidine
The discovery of pyrrolidine can be traced back to 1832, when the German chemist Johann Wolfgang Döbereiner first isolated the compound from tobacco leaves. However, it was not until 1877 that pyrrolidine was synthesized in the laboratory by the German chemist Albert Ladenburg. Since then, pyrrolidine has been widely studied, and its applications have been expanded.
Synthesis of Pyrrolidine
Pyrrolidine can be synthesized by several methods, including the reduction of pyrrole, the cyclization of amino acids, and the reaction of ammonia with α,β-unsaturated ketones. One of the most commonly used methods is the catalytic hydrogenation of pyrrole using a nickel catalyst.
Properties of Pyrrolidine
Pyrrolidine has a wide range of physical and chemical properties that make it a useful compound in various applications. Some of the properties of pyrrolidine are:
- Boiling point: 87.2 °C
- Density: 0.84 g/mL
- Melting point: -63.5 °C
- Solubility: soluble in water, ethanol, and ether
- Odor: characteristic odor
- Basicity: pKa of approximately 11
Uses of Pyrrolidine
Pyrrolidine has a wide range of uses in the chemical and pharmaceutical industries. Some of its applications are:
Pyrrolidine is used as a building block for various drugs, including:
- Piracetam: used for the treatment of cognitive disorders
- Biperiden: used for the treatment of Parkinson's disease
- Loperamide: used for the treatment of diarrhea
Pyrrolidine is used as a solvent, catalyst, and intermediate in the production of various chemicals, including:
- Rubber accelerators
Health and Safety Considerations
Pyrrolidine is a hazardous compound that can cause severe health effects if not handled properly. It can cause skin and eye irritation, respiratory problems, and central nervous system depression. Therefore, appropriate safety precautions must be taken when handling pyrrolidine, such as using personal protective equipment and working in a well-ventilated area.
Pyrrolidine is a versatile compound with various applications in the chemical and pharmaceutical industries. Its unique properties make it a useful building block for various drugs and chemicals. However, it is a hazardous compound that must be handled with care to avoid adverse health effects.