Chemicals

Cyclohexylamine

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Chemical Name	Cyclohexylamine
Synonyms	1-Aminocyclohexane; 1-Cyclohexylamine; Aminocyclohexane; Aminohexahydrobenzene; Hexahydrobenzenamine; Biodur E 1; HY; Hexahydroaniline; Monocyclohexylamine; Glipizide EP Impurity B
Impurity	Glipizide EP Impurity B
CAS Number	108-91-8
Molecular Formula	C₆H₁₃N
Appearance	Colourless Oil
Molecular Weight	99.17
Storage	20°C, Inert atmosphere
Solubility	Chloroform (Slightly), Methanol (Slightly)
Category	Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
Applications	Cyclohexylamine (Glipizide EP Impurity B) is a building block for pharmaceuticals that has been used for the preparation of paromomycin analogs to be used as aminogycoside antibiotics.
	Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Cyclohexylamine: Properties, Applications, and Safety

Cyclohexylamine (CHA) is a colorless to yellow liquid with an amine-like odor. It is a versatile compound used in various applications, including pharmaceuticals, rubber chemicals, agrochemicals, and surfactants. However, CHA can also be hazardous if not handled properly. In this article, we will discuss the properties, applications, safety concerns, and regulations related to CHA.

Properties of Cyclohexylamine

Cyclohexylamine has the chemical formula C6H13N and a molecular weight of 99.17 g/mol. It has a boiling point of 134-135 °C and a melting point of -17.7 °C. CHA is soluble in water, ethanol, and ether and has a pH of around 11-12. It is a weak base, and its pKa is around 10.5.

Applications of Cyclohexylamine

Pharmaceutical Industry

CHA is used as an intermediate in the synthesis of various pharmaceutical compounds. For example, it is a building block in the production of antihistamines, antidepressants, and anti-inflammatory drugs.

Rubber Chemicals

CHA is also a critical component in the production of rubber chemicals, such as accelerators, antioxidants, and vulcanization agents. These chemicals improve the properties of rubber, such as elasticity, durability, and heat resistance.

Agrochemicals

CHA is used in the synthesis of herbicides, insecticides, and fungicides. For example, it is a building block for the production of glyphosate, a widely used herbicide.

Surfactants

CHA is used in the production of surfactants, such as detergents, emulsifiers, and wetting agents. These compounds have a wide range of applications, including cleaning, agriculture, and oil recovery.

Safety Concerns and Regulations

Although CHA has various applications, it can also pose safety concerns if not handled properly. It is a corrosive substance that can cause severe skin and eye irritation, burns, and respiratory problems. CHA is also flammable and can form explosive mixtures with air. Therefore, it is essential to follow proper handling and storage procedures when working with CHA.

Various regulations govern the production, handling, and use of CHA. For example, the European Union classifies CHA as a hazardous substance under the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) regulation. The United States Occupational Safety and Health Administration (OSHA) also regulates CHA under the Hazard Communication Standard (HCS). These regulations mandate the proper labeling, handling, and storage of CHA and provide guidelines for exposure limits and personal protective equipment.

Conclusion

Cyclohexylamine is a versatile compound used in various applications, including pharmaceuticals, rubber chemicals, agrochemicals, and surfactants. However, it can also pose safety concerns if not handled properly. It is essential to follow proper handling and storage procedures and adhere to regulations when working with CHA. By doing so, we can utilize the benefits of CHA while minimizing the risks associated with it.