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4′-Methylpropiophenone
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| Chemical Name | 4′-Methylpropiophenone |
| Synonyms | 4'-Methylpropiophenone; 1-(4-Methylphenyl)-1-propanone; 1-(4-Tolyl)-1-propanone; 4'-Methylpropiophenone; Ethyl 4-Methylphenyl Ketone; Ethyl p-Tolyl Ketone; NSC 852; p-Methylpropiophenone |
| CAS Number | 5337-93-9 |
| Molecular Formula | C₁₀H₁₂O |
| Appearance | Colourless Oil |
| Molecular Weight | 148.2 |
| Storage | 20°C |
| Solubility | Chloroform (Soluble), Ethyl Acetate (Sparingly), Hexanes (Slightly) |
| Category | Building Blocks; Miscellaneous; |
| Applications | 4тА▓-Methylpropiophenone is a chemical reagent used in electrocarboxylation reactions. |
4'-Methylpropiophenone, also known as para-methylpropiophenone, is an organic compound with the chemical formula C10H12O. It is a colorless to light yellow liquid with a distinct aromatic odor. It is commonly used as a precursor in the synthesis of various pharmaceuticals and agrochemicals.
Synthesis of 4'-Methylpropiophenone
The synthesis of 4'-Methylpropiophenone can be achieved through several methods. One common method involves the reaction between para-tolualdehyde and propanoic acid in the presence of a catalyst such as aluminum chloride. Another method involves the reaction between acetophenone and methylmagnesium bromide in the presence of a copper(I) catalyst.
Applications of 4'-Methylpropiophenone
4'-Methylpropiophenone is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is used as a precursor in the synthesis of the antidepressant drug fluoxetine (Prozac) and the antipsychotic drug olanzapine (Zyprexa). It is also used in the synthesis of the herbicide bromacil and the insecticide cypermethrin.
Safety considerations
4'-Methylpropiophenone is considered to be a hazardous substance, and precautions should be taken when handling it. It can cause irritation to the skin, eyes, and respiratory system. Ingestion or inhalation of the substance can cause nausea, vomiting, and headaches. It should be stored in a cool, dry, and well-ventilated area away from sources of ignition and incompatible materials.
FAQs about 4'-Methylpropiophenone
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What is 4'-Methylpropiophenone used for? 4'-Methylpropiophenone is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals.
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Is 4'-Methylpropiophenone safe to handle? 4'-Methylpropiophenone is considered to be a hazardous substance, and precautions should be taken when handling it. It can cause irritation to the skin, eyes, and respiratory system.
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What are the hazards associated with 4'-Methylpropiophenone? Ingestion or inhalation of the substance can cause nausea, vomiting, and headaches. It should be stored in a cool, dry, and well-ventilated area away from sources of ignition and incompatible materials.
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What is the chemical formula of 4'-Methylpropiophenone? The chemical formula of 4'-Methylpropiophenone is C10H12O.
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What are the synthesis methods for 4'-Methylpropiophenone? The synthesis of 4'-Methylpropiophenone can be achieved through several methods, including the reaction between para-tolualdehyde and propanoic acid, and the reaction between acetophenone and methylmagnesium bromide.
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What are the applications of 4'-Methylpropiophenone? 4'-Methylpropiophenone is used as a precursor in the synthesis of various pharmaceuticals and agrochemicals, including fluoxetine and olanzapine.
Conclusion
4'-Methylpropiophenone is an organic compound that is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It can be synthesized through several methods and is used in the synthesis of fluoxetine, olanzapine, bromacil, and cypermethrin.