Chemicals

1-Methyl-2-pyrrolidinone

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Chemical Name	1-Methyl-2-pyrrolidinone
Synonyms	1-Methyl-5-pyrrolidinone; 1-Methylazacyclopentan-2-one; 1-Methylpyrrolidone; AgsolEx 1; M-Pyrol; Microposit 2001; N 0131; N-Methyl-2-ketopyrrolidine; N-Methyl-γ-butyrolactam; N-Methylbutyrolactam; N-Methylpyrrolidone; NMP; NSC 4594; Pharmasolve; Pyrol M; SL 1332; N-methyl-2-pyrrolidone
CAS Number	872-50-4
Molecular Formula	C₅H₉NO
Appearance	Pale Beige to Dark Brown Solid
Molecular Weight	99.13
Storage	4°C
Solubility	Chloroform, DMSO (Slightly), Methanol (Slightly)
Category	Building Blocks; Miscellaneous;
Boiling Point	202┬░C @ 760 Torr (Scifinder)
Applications	It is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.

1-Methyl-2-pyrrolidinone: Properties, Uses, and Safety Considerations

1-Methyl-2-pyrrolidinone, also known as N-methylpyrrolidone (NMP), is a highly polar organic compound with the molecular formula C₅H₉NO. It is a clear, colorless liquid that is miscible with water and has several industrial and pharmaceutical applications. In this article, we will discuss the properties, uses, and safety considerations of 1-methyl-2-pyrrolidinone.

Properties of 1-Methyl-2-pyrrolidinone

1-Methyl-2-pyrrolidinone has several physical and chemical properties that make it a valuable compound in various industries. Some of these properties include:

Physical Properties

Molecular weight: 99.13 g/mol
Melting point: -24 °C (-11 °F)
Boiling point: 202 °C (396 °F)
Density: 1.03 g/cm³
Solubility in water: Miscible

Chemical Properties

1-Methyl-2-pyrrolidinone is a highly polar aprotic solvent
It is a strong solubilizing agent for a wide range of organic and inorganic compounds
It can be used as a reactant in a variety of chemical reactions
It is relatively stable and does not readily undergo chemical reactions under normal conditions

Uses of 1-Methyl-2-pyrrolidinone

1-Methyl-2-pyrrolidinone has several industrial and pharmaceutical applications. Some of the most common uses of 1-methyl-2-pyrrolidinone include:

Electronics

1-Methyl-2-pyrrolidinone is used in the electronics industry as a solvent for the production of photoresist and solder masks. It is also used as a cleaning agent for electronic components.

Pharmaceuticals

1-Methyl-2-pyrrolidinone is used in the pharmaceutical industry as a solvent for the production of drug formulations. It is also used as a penetration enhancer for transdermal drug delivery systems.

Petrochemicals

1-Methyl-2-pyrrolidinone is used in the petrochemical industry as a solvent for the separation of aromatic hydrocarbons. It is also used as a reactant in the production of certain chemicals, such as caprolactam.

Other Uses

1-Methyl-2-pyrrolidinone is also used in the production of polymers, resins, and fibers. It can be used as a solvent for the extraction of natural products, such as caffeine and nicotine. It is also used as a heat transfer fluid and a lubricant.

Safety Considerations

1-Methyl-2-pyrrolidinone is generally considered safe when handled properly. However, it can be toxic if ingested or inhaled in large quantities. Some of the safety considerations for handling 1-methyl-2-pyrrolidinone include:

Wear appropriate protective gear, including gloves and goggles
Handle 1-methyl-2-pyrrolidinone in a well-ventilated area
Avoid ingestion or inhalation of 1-methyl-2-pyrrolidinone
Store 1-methyl-2-pyrrolidinone in a cool, dry, and well-ventilated area away from sources of heat and ignition
Dispose of 1-methyl-2-pyrrolidinone according to local regulations